Another significant challenge in computer accessibility is to make software usable by people with visual impairment, since computer interfaces often solicit input visually and provide visual feedback in response. For individuals with mild to medium vision impairment, it is helpful to use large fonts, high DPI displays, high-contrast themes and icons supplemented with auditory feedback and screen magnifying software.

In the case of severe vision impairment such as blindness, screen reader software that provides feedback via text to speech or a refreshable braille display is a necessary accommodation for interaction with a computer.

About 8% of people, mostly males, suffer from some form of colour-blindness. In a well-designed user interface, colour should not be the only way of distinguishing between different pieces of information. However, the only colour combinations that matter are those that people with a deficiency might confuse, which generally means red and green and blue and green.