Some people may not be able to use a conventional input device, such as the mouse or the keyboard. Therefore it is important for software functions to be accessible using both devices; ideally, software uses a generic input API that permits the use even of highly specialized devices unheard of at the time of software development. Keyboard shortcuts and mouse gestures are ways to achieve this. More specialized solutions like on-screen software keyboards and alternate input devices like switches, joysticks and trackballs are also available. Speech recognition technology is also a compelling and suitable alternative to conventional keyboard and mouse input as it simply requires a commonly available audio headset.

The astrophysicist Stephen Hawking is a famous example of a person suffering from motor disability. He uses a switch, combined with special software, that allows him to control his wheelchair-mounted computer using his remaining small movement ability. This performs as a normal computer, allowing him to research and produce his written work, and as an Augmentative and Alternative Communication and environmental control device.